Among the quantitative methods of blood examination, red-cell count and hematocrit
determination have been frequently used. However, Berlin et al.(1952) suggested that the
red-cell counts had often been misleading and the determination of the volume had been
of great importance in handling of major medical and surgical problems.
Since the original description of in vitro red-cell labelling with radioactive
32p (Hahn and Hevesy 1940), there have been a number of reports on the
determination of the blood volume by diffusible substances.
Wochner and Potchen(1970) developed a simple and accurate new method to estimate
plasma volume with the initial distribution space of Indium-113m transferrin. Based on
this fact, the author estimated plasma volume using 113mIn labelling
technique in healthy men and patients with liver diseases who were admitted to the
Medical Department of Severance Hospital, Yonsei University.
There have been a few reports on blood volume with the use of 113mIn,
but no available data in Korea concerned with the normal male group and pathological
states such as liver diseases including hepatoma, hepatitis and cirrhosis.
In this study, the mean value of the plasma volume per kg of body weight was 45.3
±6.1 ㎖ in normal controls, 58.1±8.8 ㎖ in patients with liver cirrhosis, 60.7±4.2 ㎖ in
hepatoma and 40.5±4.3 ㎖ in hapetitis. The mean plasma volumes in patients with
cirrhosis and hepatoma were significantly higher than the controls.
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